S. R. Chhabra, H. Parekh, Azra N Khan
Mar 11, 2001
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
The Dde-derived carboxy protecting group, 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester (ODmab) has been developed into a carboxy functional linker. The stability of the linker to standard acid and base conditions employed in Fmoc/tBu SPPS has been demonstrated and its utility illustrated by the construction of model peptides, Leu-enkephalin and Human Angiotensin II.