C. Blackburn, B. Guan
Mar 4, 2000
Citations
0
Influential Citations
66
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The three-component synthesis of 3-aminoimidazo[1,2- a ]pyridine derivatives has been extended by a novel acid-induced dealkyation reaction that removes the 1,1,3,3-tetramethylbutyl group derived from the isonitrile input. This reaction was conducted on the solid-phase using the HMBA linker and the resulting products subjected to reductive alkylation using several aldehydes, thereby accessing novel substitution patterns at the 3-position.