Clayden, Menet, Mansfield
Nov 29, 2000
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0
Influential Citations
39
Citations
Journal
Organic letters
Abstract
On treatment with LDA, substituted N-benzylbenzamides (including those bearing electron-withdrawing, electron-donating, or conjugating groups) become lithiated and cyclize to give, after aqueous quench, a range of partially saturated isoindolones as single regio- and stereoisomers. In general, the isoindolones resist rearomatization. Reaction of N-cumyl-N-benzylbenzamides leads to cyclized products which may be deprotected to give N-unsubstituted isoindolones.