J. Oates, L. Gillespie, S. Udenfriend
Jun 24, 1960
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0
Influential Citations
223
Citations
Quality indicators
Journal
Science
Abstract
α-Methyl-3,4-dihydroxy-DLphenylalanine has been found to be an effective inhibitor of aromatic amino acid decarboxylation in man. This was shown by decreased formation of serotonin, tryptamine, and tyramine from the precursor amino acids. Reduction of amine biosynthesis is associated with lowering of blood pressure in hypertensive patients and a transient sedative effect.