H. Kantarjian, J. Issa, C. Rosenfeld
Apr 15, 2006
Citations
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Influential Citations
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Quality indicators
Journal
Cancer
Abstract
Aberrant DNA methylation, which results in leukemogenesis, is frequent in patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic therapy. Decitabine indirectly depletes methylcytosine and causes hypomethylation of target gene promoters.