Bradley B. Brown, D. Wagner, H. Geysen
Sep 1, 1995
Citations
1
Influential Citations
40
Citations
Journal
Molecular Diversity
Abstract
SummaryA new linker that employs a photosensitive 3-ammo-3-(2-nitrophenyl)propionyl functionality (ANP-resin) has been developed for the preparation of C-terminal carboxamides. A wide range of carboxamides were prepared and identified using the ANP-resin and electrospray ionization mass spectrometry. A single bead containing tripeptide Fmoc-Asp-Arg(Tos)-Val-NH2 was isolated, photocleaved and the peptide was characterized by tandem mass spectrometry, thereby verifying a library decode strategy that avoids complex tagging procedures.