Wei Zhou, D. Moore
Sep 12, 1994
Citations
5
Influential Citations
75
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
Sulfamethoxazole (4-amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide) is extremely photolabile in acidic aqueous solution, giving rise to at least five primary photoproducts. The major product has been identified as 4-aminoN-(5-methyl-2-oxazolyl)benzenesulfonamide resulting from photoisomerization of the isoxazole ring. This product was found to exist predominantly in its imido tautomeric form. Other products include sulfanilic acid, aniline, 3-amino-5-methylisoxazole and a hydrated product. The pathways leading to the formation of the products are postulated.