L. D. Ketchum, D. Robinson, F. Masters
Jul 1, 1967
Citations
0
Influential Citations
50
Citations
Journal
Plastic and Reconstructive surgery
Abstract
The use of triamcinolone (9-a-fluorohy drocortisone acetonide) has been advocated in the treatment of hypertrophic scars and keloids. A controlled clinical series of the intralesional use of this steroid revealed that approximately 90 per cent of all hypertrophic scars and keloids respond.1 Two burn pa tients in the reported clinical series were biopsied at weekly intervals following intra lesional triamcinolone, and the analysis of the soluble collagen fraction of the mature scar revealed a time dependent increase in solubility. To try and determine the biologic effect of the steroid therapy, a series of laboratory experiments were undertaken to determine both the in vivo and in vitro effect of this steroid upon mature collagen.