Peng Zhong, B. Pan, Xiu-ping Gao
Oct 1, 2011
Citations
2
Influential Citations
57
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Journal
The Journal of Physiology
Abstract
Non‐Technical Summary 2‐Arachidonoylglycerol (2‐AG) is an endogenous marijuana‐like chemical that regulates synaptic transmission via the stimulation of the type I cannabinoid receptor (CB1). It is inactivated by an enzyme called monoacylglycerol lipase (MAGL). 2‐AG inactivation is impaired in MAGL knockout mice. We show that 2‐AG accumulation in the brain of MAGL knockout mice alters several forms of 2‐AG‐mediated synaptic depression in the cerebellum via tonic activation and desensitization of CB1 receptors.