H. Hui, J. Robinson
Oct 1, 1985
Citations
1
Influential Citations
134
Citations
Quality indicators
Journal
International Journal of Pharmaceutics
Abstract
Abstract Polymers of acrylic acid crosslinked (0.3% w/w) with divinyl glycol and 2,5-dimethyl-1,5-hexadiene were synthesized and examined as to their utility in ocular drug delivery. Both showed excellent bioadhesion to the conjunctival mucin/epithelial layer as determined by visual inspection and a sensitive in vitro method. The densities and extent of hydration of the polymers were also determined. Progesterone was used as a model drug which was entrapped in the polymer of acrylic acid crosslinked with 2,5-dimethyl-1,5-hexadiene. A suspension without polymer was prepared at the same progesterone concentration and used as a control for ocular bioavailability comparison. From the 1 h determination through the end of the study, the aqueous humor drug levels showed a statistically significant difference between the test and control formulations. The bioadhesive dosage form showed an area under the curve 4.2 times greater than the results obtained for the suspension preparation, over the time course of the study.