Ivan Zlatev, A. Giraut, F. Morvan
Oct 1, 2009
Citations
0
Influential Citations
29
Citations
Journal
Bioorganic & medicinal chemistry
Abstract
The replacement of the pyrophosphate moiety of 2'-deoxynucleoside triphosphates by non natural delta-dicarboxylic butyl amino acid allows incorporation of natural 2'-deoxycytidine into DNA using HIV-1 reverse transcriptase (RT) as enzyme. In contrast, the 3'-deoxycytidine analogue was not a substrate of the HIV-1 RT.