Srinivasabhatt Aswanikumar, Barbara Corcoran, Elliot Schiffmann
Jan 24, 1977
Citations
4
Influential Citations
318
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract [3H]formylNorleu-Leu-Phe, a potent leucocyte chemoattractant, binds specifically to a site on rabbit neutrophils with an affinity of 1.5 × 10−9 M. Other acylated peptide chemoattractants displace this binding at concentrations closely related to those levels required to elicit chemotaxis. The binding fulfills the major criteria for demonstration of specific receptor sites and indicates that a natural bacterial product and synthetic formyl-peptides produce chemotaxis by the same receptor mechanism.