Kazuhiko Takahashi, Masatsugu Kamiya, Yoko Sengoku
Nov 25, 1988
Citations
3
Influential Citations
34
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
3-Fluoro-, 2-and 3-chloro-quinolines were deficient in mutagenicity in S. typhimurium TA100, whereas all the other fluoro and chloro derivatives examined were mutagenic. Together with mutagenic property of methylquinolines, the mutagenic metabolite of quinoline is presumed to be the 2, 3-dihydro-2, 3-epoxide of 1, 4-hydrate form of quinoline. A possibility is proposed that a fluorine substitution may deprive the aromatic compounds of the genotoxicity.