T. Scattolin, T. Gharbaoui, Cheng-yi Chen
May 13, 2022
Citations
0
Influential Citations
3
Citations
Journal
Organic letters
Abstract
Carbamates, typically used for the protection of amines, including Cbz, Alloc, and methyl carbamate, can be readily deprotected by treatment with 2-mercaptoethanol in the presence of potassium phosphate tribasic in N,N-dimethylacetamide at 75 °C. This nucleophilic deprotection protocol is superior to the standard hydrogenolysis or Lewis acid-mediated deprotection conditions for substrates bearing a functionality sensitive to these more traditional methods.