J. L. Sirks
2007
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0
Influential Citations
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Quality indicators
Journal
Antonie van Leeuwenhoek
Abstract
SummaryVarious derivatives of P.A.B. obtained by introduction of substituents in the benzene-nucleus have been examined for their action on the growth ofAerobacter aerogenes in a simple synthetic medium and ofDiplococcus pneumoniae in ascites-broth without peptone.The following results have been obtained:1.The 2-amino, 3-amino, 3-chloro, 3-bromo, 2-methyl, 3-methyl, and 2.3-dimethyl derivatives of P.A.B., and also 2-sulfanilamido-4-aminobenzoic acid have sulfonamide activity.2.The 2-hydroxy, 2-fluoro, and 2-nitro derivatives have an antisulfonamide activity similar to the activity of P.A.B., although weaker.3.The 3-hydroxy, 2-chloro, and 2-bromo derivatives show sulfonamide-activity in relatively high concentrations. In lower concentrations they act as anti-sulfonamides.4.The 3-nitro, 2.6-dimethyl, and 3.5-dimethyl derivatives, and methyl 2-acetamino-4-amino-benzoate are completely inactive. These results have been compared with those of other investigators and the causes of some contradictions have been elucidated.