R. N. Vyzhdak, A. Danielová, V. Kiselev
Jun 1, 2005
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Journal
Russian Journal of General Chemistry
Abstract
Treatment of N-(2,2,2-trichloro-1-tosylethyl)dichloroacetamide with excess dimethylamine, piperidine, or morpholine gave substituted aminals of the oxazole series, whose facile acid hydrolysis provided 5-(dimethylamino)-4-tosyl-1,3-oxazol-2-carbaldehyde and its analogs having the piperidino and morpholino group in the 5 position of the oxazole ring. The resulting aldehydes and their aminals were condensed with phenylhydrazine, thiosemicarbazide, N-alkylrhodanines, and 1,3-dimethylbarbituric acid to obtain 2,5-disubstituted derivatives of 4-tosyl-1,3-oxazole.