J. Goto, M. Hasegawa, Setsuko Nakamura
Jun 23, 1978
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Journal
Journal of Chromatography A
Abstract
Abstract A new derivatization procedure has been developed for converting enantiomeric amines into diastereomers for resolution by high-performance liquid chromatography. Two chiral reagents, (−)- a -methoxy- a -methyl-1-naphthaleneacetic acid and (−)- a -methoxy- a -methyl-2-naphthaleneacetic acid, were prepared and optically resolved by fractional crystallization of their (+)- a -methylbenzylamine salts. The diastereomeric amides formed from amino acid methyl esters and (−)- a -methoxy- a -mthyl-1-naphthaleneacetic acid by the N,N′-dicyclohexylcarbodiimide method were efficiently resolved on a normal-phase column and responded with satisfactory sensitivity in the ultraviolet detector.