L. Orris
Jul 1, 1973
Citations
0
Influential Citations
0
Citations
Journal
International Journal of Dermatology
Abstract
Candicidin, an antifungal antibiotic derived from the soil actinomycete Slreplomyccs griseus, has heen demonslrated in vitro^ and in vivo^3' 4,5 LQ be effective against certain yeast-like organisms. Chemically, candicidin is an aromatic polyene compound similar in slructme to nystatin, candidin and amphotericin B. However, Lcchevalier'' has foinid candicidin to be over 50 times more active against yeast-like organisms than nystatin and 10 times more ellective tlian either candidin or amphotericin B. Similar comparative results were reported by McCoy and Kiscr,'' who exjjerirnented in vivo using mice preinfectecl witli Candida nlhicans prior to subcutaneous administration of the antibiotics. The antimonilial action oC candicidin lias been extensively demonstrated in vivo in tlie treatment of vaginal candidiasis.-^'• ^ Tlie dermatological anticancHdal activity of candicidin was demonstrated by Dick,^ who tested the antibiotic in the form of an ointment. 1 evaluated candicidin in the form of a spray powder i'or dermatological application.* This dosage form provides the anhydrous medium required ito insure the antibiotic's stability. In addition, the dosage form offers an excellent vehicle for uniform therapeutic application. From a therapeutic standpoint, since many dermatoses due to Candida are associated with a