F. Camps, M. Baldellou, X. Belles
1983
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Abstract
Abstract Several series of compounds have been prepared, based on particular structural modifications of natural precocenes, with the aim of improving the AJH biological activity of these compounds. In this context, to study the influence of the pyran ring of the chromene structure on AJH activity, 7-alkoxy or 6,7-dialkoxy-2,2-dimethyl-2H-thiachromenes (thiaprecocenes), 1,1-dimethylindenes and 3,3-dimethyl-2-methylidene-2,3-dihydrobenzofurans, have been synthesized by straightforward sequences. Likewise, dihydrobenzodipyrans, which can be envisaged as precocene analogues with an encumbered 7-alkoxy substituent, have also been prepared by an original procedure. On the other hand, in relation to our strategy of incorporation of ionophoric moieties in the precocene structure, the synthesis of precocene analogues bearing polyoxyethylenated and sugar residues as substituents is also described. Preliminary results of AJH activity, assays on the bug Oxycarenus lavaterae (Heteroptera, Lygaeidae) with P1, P2 and ethoxyprecocene 2(EP-2), according to a methodology developed in this laboratory, will also be reported.