W. Brouillette, V. Atigadda, M. Luo
Jul 19, 1999
Citations
0
Influential Citations
27
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3-guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.