K. Nicolaou, W. Dai, Y. Hong
Sep 1, 1993
Citations
0
Influential Citations
65
Citations
Journal
Journal of the American Chemical Society
Abstract
A series of enediyne model systems of the dynemicin A type equipped with triggering and modulating/signaling devices were designed, synthesized, and studied. Specificaly, compounds 16, 18, 25, and 27 were synthesized via ring closures involving intramolecular acetylide additions to carbonyl groups followed by deoxygenation. Compounds 16 and 25 underwent cycloaromatization to systems 28 and 29, respectively, upon acid treatment