T. J. Roseman, J. Biermacher, R. Bennett
1986
Citations
0
Influential Citations
6
Citations
Journal
Journal of Controlled Release
Abstract
Abstract Permeabilities of carboprost methyl (15(s)-15 methyl prostaglandin F 2 α methyl ester) were determined for a series of synthetic polymeric membranes. Membrane compositions consisted of a polyurethane ether and a series of poly(co-ethylene) vinyl acetate copolymers with vinyl acetate concentrations varying from 9% w/w to 60% w/w. Permeability increased as a function of the percent vinyl acetate in the copolymer. The increase in permeability was mainly due to an increase in the solubility of carboprost methyl in the polymer. Diffusion coefficients were independent of vinyl acetate concentrations above 9% w/w. The highest permeability and solubility value was associated with the polyurethane polymer. Membranes of identical composition yielded different transport rates depending upon the method of preparation (casted versus blown) and transport rates were inversely related to the thickness of the membrane. Permeability was shown to be a key parameter in determining the sequencing of polymeric membranes in the design of laminated controlled release delivery systems for carboprost methyl.