M. Yokoyama, S. Inoue, K. Kataoka
Sep 1, 1989
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0
Influential Citations
85
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Quality indicators
Journal
Macromolecular Chemistry and Physics
Abstract
Synthesis of a novel conjugate of anticancer drug adriamycin, poly(ethylene glycol)-block-poly(aspartic acid), and immunoglobulin G is reported. Poly(ethylene glycol)-block-poly(aspartic acid), binding adriamycin on the poly(aspartic acid) chain, showed an excellent water-solubility despite the introduction of a large amount of strongly hydrophobic adriamycin, and was found to form a micellar structure in aqueous solution. Efficient coupling between poly(ethylene glycol)-block-poly(aspartic acid) binding adriamycin and immunoglobulin G was achieved via disulfide linkages.