K. J. M. Swapnaja, Satyanarayana Yennam, M. Chavali
Feb 14, 2019
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A series of novel 1, 2, 4-triazolo isoquinoline derivatives (8a-8p) were synthesized starting from 2-phenylethan-1-ol derivative (1) in a 7 step synthetic sequence. The key step in the scheme involves 1, 3-dipolar [3 + 2] cycloaddition of azomethine imine and ethyl cyanoformate as unknown reaction protocol. We have demonstrated the hydrolysis of both ester and benzoyl group in a single step and the corresponding carboxylic acid derivatives were coupled with various amines to generate unknown 1, 2, 4-triazolo isoquinoline derivatives The structures of the compounds (8a-8p) were characterized by 1H NMR, 13C NMR and HRMS analysis.