Tannaz Zebardast, A. Zarghi, Bahram Daraie
Jun 15, 2009
Citations
2
Influential Citations
63
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A new group of 3-alkyl-2-aryl-1,3-thiazinan-4-ones, possessing a methylsulfonyl pharmacophore, were synthesized and their biological activities were evaluated for cyclooxygenase-2 (COX-2) inhibitory activity. In vitro COX-1/COX-2 inhibition studies identified 3-benzyl-2-(4-methylsulfonylphenyl)-1,3-thiazinan-4-one (11a) as a potent (IC(50)=0.06 microM) and selective (selectivity index >285) COX-2 inhibitor.