Tengfei Qu, Lailiang Qu, Xiaoguang Wang
Feb 23, 2018
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Zeitschrift für Naturforschung C
Abstract
Abstract A series of novel 8-methoxyquinoline-2-carboxamide compounds containing 1,3,4-thiadiazole moiety was designed and synthesized by using an active substructure combination method. Then, the antibacterial activities of all the target compounds were evaluated in vitro against three Gram-positive bacteria and three Gram-negative bacteria. The antibacterial assay showed that some target compounds displayed moderate to good antibacterial efficacy in comparison with the reference drug Chloromycin. Some interesting results of structure-activity relationships were also discussed.