B. Pan, Ren-zheng Huang, Shi-qing Han
Apr 15, 2010
Citations
1
Influential Citations
47
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 microM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.