B. Ravinaik, M. Rao, P. P. Rao
Apr 1, 2021
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Journal
Russian Journal of Organic Chemistry
Abstract
Abstract A series of substituted N -(4-{5-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-4-(2,3,4-trimethoxyphenyl)-1,3-thiazol-2-yl}phenyl)benzamides were designed and synthesized starting from 2-(4-methylphenyl)acetic acid, 1,2,3-trimethoxybenzene, and substituted benzoyl chlorides. The synthesized compounds were evaluated for anticancer activity against four cancer cell lines: MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer), and A2780 (ovarian cancer). Most of the tested compounds exhibited moderate to excellent anticancer activity in comparison to etoposide used as reference drug with the IC 50 values ranging from 0.013±0.001 to 17.38±6.43 µM against 0.17±0.034 to 3.34±0.152 µM for etoposide. Five derivatives showed higher anticancer activities than the reference drug.