Nidhi Singh
May 1, 2019
Citations
1
Influential Citations
4
Citations
Journal
Letters in Drug Design & Discovery
Abstract
A series of novel substituted 2-mercaptoimidazoles was synthesised efficiently and in high yields using one-pot synthesis from m-hydroxyacetophenones. The structures of the newly synthesized compounds were established, their molecular activity was investigated against some bacteria and fungi were further validated using molecular docking study. Reaction of o-hydroxyphenacylbromide (2) with substituted aniline and KSCN, in the presence of catalyst p-toluene sulfonic acid afforded 4(a-r) in good yield. The structure of compounds (4a-r) was confirmed by IR, NMR and MS. The compounds exhibited excellent antimicrobial potency against the tested microorganism.