S. Bromidge, F. Brown, F. Cassidy
Aug 1, 1992
Citations
0
Influential Citations
7
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract Replacement of the ester group of methyl quinuclidine-3-carboxylate 2 with an oxime ether afforded a series of potent muscarinic agonists with efficacies ranging from full to partial agonism. From an investigation of the relationship between central selectivity and efficacy, the propargyl ether 5g emerged as a high affinity partial agonist with a good separation between central and peripheral actions.