Sanjiv Kumar, B. Narasimhan, S. Lim
May 31, 2019
Citations
1
Influential Citations
4
Citations
Quality indicators
Journal
Mini reviews in medicinal chemistry
Abstract
Pyrimidine derivatives attracted organic chemists very much due to their biological and chemotherapeutic importance. A series of pyrimidine scaffolds of 5-(2-amino-6-(3/4-bromophenyl)pyrimidin-4-yl)benzene-1,3-diol derivatives was synthesized by Claisen-Schmidt condensation and its chemical structures were confirmed by physicochemical properties and spectral data (NMR, IR, Mass and elemental analyses) study. The synthesized compounds were screened their in vitro antimicrobial activity against bacterial and fungal strains by tube dilution method and anticancer activity against HCT-116 cancer cell line by SRB assay method. The antimicrobial results demonstrated that compounds, k6, k12, k14 and k20 were found to be most potent ones. The anticancer results indicated that compounds, k8 and k14 displayed potent anticancer activity against HTC116 cell line.