Hanumantharao Bommena, Venkata Subramanyeswara Rao Inti, Ravikanth Vysyaraju
Mar 31, 2015
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Journal
International Journal of Bioassays
Abstract
The stereo selective novel synthesis of (3S,3aR,6aS)-Hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-(4-amino-N-isobutylphenylsulfonamido)-1-(4-fluorophenyl)-2-hydroxypropylcarbamate (1), it involves the eight synthetic steps mainly which was accomplished from the intermediate 4-Amino-N-((2R,3S)-3-amino-3-(4-fluorophenyl)-2-hydroxypropyl)-N-isobutyl benzenes sulfonamide. This reaction gave 88% yield, with an optical purity of 99.5% and purity of 99% for chiral alcohol.