Someshwar D. Dindulkar, I. Bhatnagar, R. Gawade
May 28, 2014
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Journal
Journal of Chemical Sciences
Abstract
AbstractA series of fifteen diversified N-benzylpiperidin-4-one oximes were synthesized and characterized by their NMR spectral data. Additionally, single-crystal XRD analysis was performed for the representative symmetrically and unsymmetrically substituted molecules. All the synthesized oximes from unsymmetrical ketones existed as E-isomer as witnessed by their NMR and XRD data. Among the synthesized target compounds that evaluated for their in vitro cytotoxicity against human cervical carcinoma (HeLa) cells, five compounds were potent with IC50 < 17 μM. 1-Benzyl-2,6-bis(4-isopropylphenyl)-3-methylpiperidin-4-one oxime 3c with an IC50 of 13.88 μM was found to be the best active compound as depicted by the microscopic analysis. Graphical AbstractA series of fifteen diversified N-benzylpiperidin-4-one oximes were synthesized and characterized by their NMR spectral data. Single-crystal XRD analysis was performed for the representative symmetrically and unsymmetrically substituted molecules. All the synthesized oximes from unsymmetrical ketones existed as Eisomer. Among the synthesized target compounds that were evaluated for in vitro cytotoxicity against human cervical carcinoma (HeLa) cells, 1-benzyl-2,6- bis(4-isopropylphenyl)-3-methylpiperidin-4-one oxime with an IC50 of 13.88 μM was most potent.