B. Das, G. Kabalka
Aug 4, 2008
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
Abstract ( E )-4-((3-Ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl)benzoic acid, 6 , was synthesized in 87% starting from β-cyclocitral. The target compound 6 was synthesized starting from 1 via a Grignard reaction to form alcohol 2 . Compound 2 was converted to Wittig salt 3 by treatment with aldehyde 4 in butyllithium and hexane at −78 °C to form ester 5 . Ester 5 was saponified and, following acidification, acid 6 was isolated as white solid yield 87%.