Y. Aoyama, M. Uenaka, M. Kii
Nov 1, 2001
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Influential Citations
53
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Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, which exhibited 3.1 nM inhibition of human chymase and enhancement of stability in human plasma (t(1/2) 6h).