S. Manivannan
Oct 28, 2020
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Indian journal of forensic and community medicine
Abstract
2, 4-dichloro-5’fluoro-1-ene-2-(4-hydroxyphenyl) phenone (EHP) was synthesized using 4hydroxybenzaldehyde and 2,4-dichloro-5-fluoro acetophenone (DFA). 4-[3-(2, 4-dichloro-5-fluorophenyl)3-oxoprop-1-en-1-yl]phenyl acrylate (EAP) was prepared by reacting EHP with acryloyl chloride using ethyl methyl ketone (EMK) as a solvent in the presence of triethylamine (TEA) as a base at 0-50. Poly (EAP) was prepared by solution polymerization technique using benzoyl peroxide (BPO) as a free radical initiator and EMK as a solvent at 70 ± 10. EHP, EAP and poly (EAP) were characterized by Infrared, proton NMR and 13C NMR techniques. Anti-microbial activity of the DFA, EHP, EAP and poly (EAP) were tested on three different ATCC microorganisms (E.coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Salmonella Typhi ATCC 6539). The minimum concentration of the drug needed to inhibit the growth of the bacteria was estimated using photometry assay method. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)