Kaimei Cho, M. Ando, Kensuke Kobayashi
Aug 15, 2009
Citations
0
Influential Citations
13
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A novel series of cyclohexanamine derivatives was designed and synthesized as potent and selective human neuropeptide Y Y1 receptor antagonists. Modification of high-throughput screening hit compound 1 resulted in the identification of compound 3i, which displays potent Y1 activity and good selectivity towards hERG K(+) channel and serotonin transporter.