Shilan Liu, Yin-hong Liu, Hongmei Wang
Oct 1, 2009
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Influential Citations
9
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
We describe herein a novel series of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective inhibitors against the CXCR2 chemokine receptor and IL-8-mediated chemotaxis of a CXCR2-expressing cell line. Furthermore, these alkyl-hydrazine series inhibitors such as 5b demonstrated acceptable metabolic stability when incubated in human and rat microsomes.