I. Vlahov, H. Santhapuram, Paul J. Kleindl
Oct 1, 2006
Citations
2
Influential Citations
112
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
An efficient synthesis of the folate receptor (FR) targeting conjugate EC145 is described. EC145 is a water soluble derivative of the vitamin folic acid and the potent cytotoxic agent, desacetylvinblastine monohydrazide. Both molecules are connected in regioselective manner via a hydrophilic peptide spacer and a reductively labile disulfide linker.