D. Subhash, K. Bhaskar
Mar 1, 2020
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Journal
Russian Journal of Organic Chemistry
Abstract
A series of novel (E)-N-{[2-(morpholin-4-yl)quinolin-3-yl]methylidene}aniline derivatives have been designed and synthesized by the reaction of 2-(morpholin-4-yl)quinoline-3-carbaldehyde with substituted anilines. The synthesized compounds were evaluated for their in vitro antimicrobial activity against various microorganisms, and molecular docking study was also performed. Some derivatives exhibited a significant activity against bacterial and fungal strains. The molecular docking study has shown the best dock score for (E)-N-(4-methylphenyl)-1-[2-(morpholin-4-yl)quinolin-3-yl]methanimine in comparison to amoxicillin.