B. Trotter, K. K. Nanda, Nathan R Kett
Oct 27, 2006
Citations
2
Influential Citations
82
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Quality indicators
Journal
Journal of medicinal chemistry
Abstract
Novel 3-cyanoisoquinoline Kv1.5 antagonists have been prepared and evaluated in in vitro and in vivo assays for inhibition of the Kv1.5 potassium channel and its associated cardiac potassium current, IKur. Structural modifications of isoquinolinone lead 1 afforded compounds with excellent potency, selectivity, and oral bioavailability.