Xiaowu Yang, Jianheng Shen, Z. Jia
2002
Citations
0
Influential Citations
0
Citations
Journal
Journal name not available for this finding
Abstract
Actinomycin D (ActD, fig. 1), containing a planar phenoxazone ring and two cyclic pentapeptides, is one of the most intensely studied anticancer drugs and is currently used to treat highly malignant tumors such as Wilms’tumor and gestational choriocarcinoma [1]. Although ActD possesses high antitumor activities, its clinical usefulness is limited by its extreme cytotoxicity. Thus, if the structure of ActD can be modified to reduce its