A. Clemente, A. Domingos, A. P. Grancho
Apr 23, 2001
Citations
0
Influential Citations
42
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the beta-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.