Hsiencheng Shih, Lynn Deng, C. Carrera
Mar 6, 2000
Citations
1
Influential Citations
33
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Novel substituted 6,7-dimethoxy-1-tetralones and 5,6-dimethoxy-1-indanones have been synthesized and evaluated for their cytotoxicity. Compounds with 3'-lipophilic, 3',5'-dilipophilic, or 3',5'-dilipophilic-4'-hydrophilic substituents on (E)-2-benzylidene moiety showed highly cytotoxic effects. The unique structure of 42 possibly matches the pharmacophore features for these cytotoxic compounds.