H. Min
2012
Citations
0
Influential Citations
5
Citations
Journal
Chemical Reagents
Abstract
A series of thieno[3,2-d]pyrimidines incorporated with a piperazine unit as putative anti-cancer agents were designed and synthesized based on the structure of protein tyrosine kinase inhibitors.Starting from mercaptoacetic acid,4-chlorothieno[3,2-d]pyrimidine was obtained by 4-step reactions through esterification,twice ring closure condensations,and substitution with chlorine.Four novel thieno[3,2-d]pyrimidines containing a piperazine unit were synthesized through the reactions of 4-chlorothieno[3,2-d]pyrimidine with piperazine derivatives in DMF.The structures were confirmed with1HNMR and HRMS.