J. Labarre, F. Sournies, S. Cros
Apr 1, 1981
Citations
0
Influential Citations
32
Citations
Quality indicators
Journal
Cancer letters
Abstract
Abstract As a result of a preliminary screening, 3 aziridino (ethylene-imino) derivatives of the thiatriazadiphosphorine ring system with formula (NPAz2)2NSOX (X = F, Az, Ph) were found to exhibit significant antitumor activity. Experiments in vivo were carried out on P388 and L1210 leukemias in female DBA 2 mice and on B16 melanoma in female C57 black mice. Both the toxicity and the antitumor activity are to a large extent determined by the sulphur-bonded group X.