G. Maengwyn-Davies, J. Fleisch, T. Pruss
Apr 1, 1972
Citations
0
Influential Citations
1
Citations
Journal
Journal of Pharmacy and Pharmacology
Abstract
Desoxyisoprenaline (N‐isopropyldopamine, DOI), an optically inactive analogue of isoprenaline, which lacks the alcoholic ‐OH group, was shown to stimulate β‐adrenoceptors in cat papillary muscle, rat aorta and rat trachea, in addition to causing a hypotensive effect in anaesthetized cats. DOI was also shown to stimulate α‐adrenoceptors in rat aorta. Furthermore, DOI blocked both α‐ and β‐adrenoceptors in rabbit aortic strips and β‐adrenoceptors in rat trachea. These different actions indicate that DOI has both adrenoceptor stimulating and blocking properties.