A. Carnell, J. Barkley, Amarjit Singh
Nov 3, 1997
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Desymmetrisation of 4-cyano-4-phenylcyclohexanone 1 has been achieved by enzyme-catalysed enantioselective alcoholysis with n-butanol of the derived racemic enol acetate 2 in tetrahydrofuran. The absolute configuration of the enol acetate (−)-(S)- 2 (100% e.e.) obtained was determined by X-ray analysis of the camphanyl derivative 7 .