T. Tsuji, Y. Iio, T. Takemoto
Oct 3, 2005
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Journal
Tetrahedron-asymmetry
Abstract
Abstract We report herein, the novel enzymatic desymmetrization of 2- tert -butoxycarbonylamino-2-methyl-1,3-propanediol 1 . This method makes it possible to prepare ( S )- N -Boc- N , O -isopropylidene-α-methylserinal 3 , which is a chiral building block for the synthesis of a variety of α-substituted alanine derivatives. Moreover, optically active (4 R )-methyl-4-[2-(thiophen-2-yl)ethyl]oxazolidin-2-one 4 , one of the key intermediates in the synthesis of a novel immunosuppressant, has been prepared by this methodology.