Meining Wang, Chu-Sheng Liu, Ji-Sheng Li
Jan 21, 2002
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Influential Citations
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Journal
Tetrahedron-asymmetry
Abstract
Abstract The enantioselective hydrolysis of 3-alkyl- and 3-arylglutaronitriles catalyzed by Rhodococcus sp. AJ270 cells, afforded the corresponding ( S )-3-substituted 4-cyanobutanoic acids with low to moderate enantiomeric purities. Additives such as acetone were found to significantly enhance the enantioselectivity of the desymmetrization, giving enantiomeric excesses of up to 95%. The synthetic potential of the homochiral product was also demonstrated by the preparation of optically active ( R )- and ( S )-4-amino-3-phenylbutanoic acids.